I'm assuming you when you create your profiles, you are selecting Copy Basic Database only and Share the same item files? More than likely, your profile has switched to Separate Database/Separate Item Files. Meaning, you now have an Items Folders inside your profile folder and it's empty.
If this has happened, you can create a new profile making sure to select the correct settings and copy over the Database Folder from the corrupted profile into the new profile. If you need the profile to be the same name, make sure to copy the Database folder to a different location, delete corrupted profile and create new one with the same name. Make sure to delete the profile from the Profiles>Setup within CAD/EST/CAM. Even if you try restore the profile.map file, it wont change the Separate Item Files setting.
Or you can copy the items folder from your actual database folder into this profile and everything will line up. If you go this route, you will now have a copy of the items and they will not be the same as your global items.